rDock

Dock 1

The above image illustrates the first binding mode solution for ASTEX system 1hwi, with an RMSD of 0.88 Å.

rDock is a fast, versatile and open-source program for docking ligands to proteins and nucleic acids. The source code is available on SourceForge. The functionality is described in the following paper:
Ruiz-Carmona, S., Alvarez-Garcia, D., Foloppe, N., Garmendia-Doval, A. B., Juhos S., et al. (2014) rDock: A Fast, Versatile and Open Source Program for Docking Ligands to Proteins and Nucleic Acids. PLoS Comput Biol 10(4): e1003571. doi:10.1371/journal.pcbi.1003571
The rDock development has stalled since 2014.

rDock homepage

RxDock

Dock 2

In red mesh, definition of the cavity obtained by execution of rbcavity program.

RxDock is a fork of rDock started in 2019 with the goal of updating the code for running on modern computer systems (including supercomputers), enabling cross-platform usage, improving the command-line and application programming interfaces, and implementing newer and better performing algorithms.
Since its inception, RxDock has gained suport for operating systems other than Linux using recent C++ compilers and the testing infrastructure has been improved. Further improvements and the first stable release are coming in 2020.

RxDock homepage